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Prion protein facilitates synaptic vesicle release by enhancing release probability

The cellular prion protein (PrP(C)) has been implicated in several neurodegenerative diseases as a result of protein misfolding. In humans, prion disease occurs typically with a sporadic origin where uncharacterized mechanisms induce spontaneous PrP(C) misfolding leading to neurotoxic PrP-scrapie fo...

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Detalles Bibliográficos
Autores principales: Robinson, Susan W., Nugent, Marie L., Dinsdale, David, Steinert, Joern R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119408/
https://www.ncbi.nlm.nih.gov/pubmed/24722203
http://dx.doi.org/10.1093/hmg/ddu171