Cargando…
Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma
BACKGROUND: Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angiogenesis, which is regulated by VEGF-A, itself alternatively spliced to form two familie...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119992/ https://www.ncbi.nlm.nih.gov/pubmed/25010863 http://dx.doi.org/10.1038/bjc.2014.342 |