Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin

Typically, pharmacokinetic–pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in uptake transporter activity can lead to variable drug concentrations in plasma without discernible impact on the effect site organ concent...

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Detalles Bibliográficos
Autores principales: Rose, R H, Neuhoff, S, Abduljalil, K, Chetty, M, Rostami-Hodjegan, A, Jamei, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120018/
https://www.ncbi.nlm.nih.gov/pubmed/25006781
http://dx.doi.org/10.1038/psp.2014.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120018/
https://www.ncbi.nlm.nih.gov/pubmed/25006781
http://dx.doi.org/10.1038/psp.2014.24

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