Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants

Inactivating mutations of the melanocortin-4 receptor (MC4R) cause early-onset severe obesity in humans. Comprehensive functional studies show that most of the inactivating mutants of the MC4R are retained intracellularly. In the present study, we investigated whether a small molecule inverse agonis...

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Detalles Bibliográficos
Autores principales: Tao, Ya-Xiong, Huang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120685/
https://www.ncbi.nlm.nih.gov/pubmed/25136332
http://dx.doi.org/10.3389/fendo.2014.00131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120685/
https://www.ncbi.nlm.nih.gov/pubmed/25136332
http://dx.doi.org/10.3389/fendo.2014.00131

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