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Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates

[Image: see text] A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide...

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Detalles Bibliográficos
Autores principales: Lee, Anna, Younai, Ashkaan, Price, Christopher K., Izquierdo, Javier, Mishra, Rama K., Scheidt, Karl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120988/
https://www.ncbi.nlm.nih.gov/pubmed/25017004
http://dx.doi.org/10.1021/ja505880r