Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

[Image: see text] The finding by scientists at Hoffmann-La Roche that cis-imidazolines could disrupt the protein–protein interaction between p53 and MDM2, thereby inducing apoptosis in cancer cells, raised considerable interest in this scaffold over the past decade. Initial routes to these small mol...

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Detalles Bibliográficos
Autores principales: Vara, Brandon A., Mayasundari, Anand, Tellis, John C., Danneman, Michael W., Arredondo, Vanessa, Davis, Tyler A., Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120989/
https://www.ncbi.nlm.nih.gov/pubmed/25017623
http://dx.doi.org/10.1021/jo501003r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120989/
https://www.ncbi.nlm.nih.gov/pubmed/25017623
http://dx.doi.org/10.1021/jo501003r

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