Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

Neprilysin is a transmembrane zinc metallopeptidase that degrades a wide range of peptide substrates. It has received attention as a potential therapy for Alzheimer’s disease due to its ability to degrade the peptide amyloid beta. However, its broad range of peptide substrates has the potential to l...

Descripción completa

Detalles Bibliográficos
Autores principales: Webster, Carl I., Burrell, Matthew, Olsson, Lise-Lotte, Fowler, Susan B., Digby, Sarah, Sandercock, Alan, Snijder, Arjan, Tebbe, Jan, Haupts, Ulrich, Grudzinska, Joanna, Jermutus, Lutz, Andersson, Christin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121237/
https://www.ncbi.nlm.nih.gov/pubmed/25089527
http://dx.doi.org/10.1371/journal.pone.0104001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121237/
https://www.ncbi.nlm.nih.gov/pubmed/25089527
http://dx.doi.org/10.1371/journal.pone.0104001

Ejemplares similares