Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

Neprilysin is a transmembrane zinc metallopeptidase that degrades a wide range of peptide substrates. It has received attention as a potential therapy for Alzheimer’s disease due to its ability to degrade the peptide amyloid beta. However, its broad range of peptide substrates has the potential to l...

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Detalles Bibliográficos
Autores principales: Webster, Carl I., Burrell, Matthew, Olsson, Lise-Lotte, Fowler, Susan B., Digby, Sarah, Sandercock, Alan, Snijder, Arjan, Tebbe, Jan, Haupts, Ulrich, Grudzinska, Joanna, Jermutus, Lutz, Andersson, Christin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121237/
https://www.ncbi.nlm.nih.gov/pubmed/25089527
http://dx.doi.org/10.1371/journal.pone.0104001

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