The role of p21-activated kinases in hepatocellular carcinoma metastasis

The p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. PAKs phosphorylate a wide spectrum of substrates to mediate extracellular signals and reg...

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Detalles Bibliográficos
Autores principales: Tse, Edith Yuk Ting, Ching, Yick Pang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121300/
https://www.ncbi.nlm.nih.gov/pubmed/25093037
http://dx.doi.org/10.1186/1750-2187-9-7
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author Tse, Edith Yuk Ting
Ching, Yick Pang
author_facet Tse, Edith Yuk Ting
Ching, Yick Pang
author_sort Tse, Edith Yuk Ting
collection PubMed
description The p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. PAKs phosphorylate a wide spectrum of substrates to mediate extracellular signals and regulate cytoskeletal remodeling, cell motility and survival. In this review, we aim to summarize the findings regarding the oncogenic role and the underlying mechanisms of PAKs signaling in various cancers, and in particular highlight the prime importance of PAKs in hepatocellular carcinoma (HCC) progression and metastasis. Recent studies exploring the potential therapeutic application of PAK inhibitors will also be discussed.
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spelling pubmed-41213002014-08-05 The role of p21-activated kinases in hepatocellular carcinoma metastasis Tse, Edith Yuk Ting Ching, Yick Pang J Mol Signal Review The p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. PAKs phosphorylate a wide spectrum of substrates to mediate extracellular signals and regulate cytoskeletal remodeling, cell motility and survival. In this review, we aim to summarize the findings regarding the oncogenic role and the underlying mechanisms of PAKs signaling in various cancers, and in particular highlight the prime importance of PAKs in hepatocellular carcinoma (HCC) progression and metastasis. Recent studies exploring the potential therapeutic application of PAK inhibitors will also be discussed. BioMed Central 2014-08-01 /pmc/articles/PMC4121300/ /pubmed/25093037 http://dx.doi.org/10.1186/1750-2187-9-7 Text en Copyright © 2014 Tse and Ching; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Tse, Edith Yuk Ting
Ching, Yick Pang
The role of p21-activated kinases in hepatocellular carcinoma metastasis
title The role of p21-activated kinases in hepatocellular carcinoma metastasis
title_full The role of p21-activated kinases in hepatocellular carcinoma metastasis
title_fullStr The role of p21-activated kinases in hepatocellular carcinoma metastasis
title_full_unstemmed The role of p21-activated kinases in hepatocellular carcinoma metastasis
title_short The role of p21-activated kinases in hepatocellular carcinoma metastasis
title_sort role of p21-activated kinases in hepatocellular carcinoma metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121300/
https://www.ncbi.nlm.nih.gov/pubmed/25093037
http://dx.doi.org/10.1186/1750-2187-9-7
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