Efficient Production of (R)-2-Hydroxy-4-Phenylbutyric Acid by Using a Coupled Reconstructed d-Lactate Dehydrogenase and Formate Dehydrogenase System

BACKGROUND: (R)-2-Hydroxy-4-phenylbutyric acid [(R)-HPBA] is a key precursor for the production of angiotensin-converting enzyme inhibitors. However, the product yield and concentration of reported (R)-HPBA synthetic processes remain unsatisfactory. METHODOLOGY/PRINCIPAL FINDINGS: The Y52L/F299Y mut...

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Detalles Bibliográficos
Autores principales: Sheng, Binbin, Zheng, Zhaojuan, Lv, Min, Zhang, Haiwei, Qin, Tong, Gao, Chao, Ma, Cuiqing, Xu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121320/
https://www.ncbi.nlm.nih.gov/pubmed/25089519
http://dx.doi.org/10.1371/journal.pone.0104204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121320/
https://www.ncbi.nlm.nih.gov/pubmed/25089519
http://dx.doi.org/10.1371/journal.pone.0104204

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