Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells

Toll like receptor (TLR)-stimulated dendritic cells (DCs) are able to overcome the inhibitory activity of regulatory T cells (Tregs) and induce the proliferation of effector T cells. TLR-activated DCs secrete a soluble factor and act directly on Tregs to convert them into interferon γ-secreting T(H)...

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Detalles Bibliográficos
Autores principales: Berk, Erik, Xu, Shuwen, Czerniecki, Brian J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121335/
https://www.ncbi.nlm.nih.gov/pubmed/25101219
http://dx.doi.org/10.4161/onci.27617
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author Berk, Erik
Xu, Shuwen
Czerniecki, Brian J
author_facet Berk, Erik
Xu, Shuwen
Czerniecki, Brian J
author_sort Berk, Erik
collection PubMed
description Toll like receptor (TLR)-stimulated dendritic cells (DCs) are able to overcome the inhibitory activity of regulatory T cells (Tregs) and induce the proliferation of effector T cells. TLR-activated DCs secrete a soluble factor and act directly on Tregs to convert them into interferon γ-secreting T(H)1-like cells that express the transcription factor T-bet.
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spelling pubmed-41213352015-01-06 Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells Berk, Erik Xu, Shuwen Czerniecki, Brian J Oncoimmunology Author's View Toll like receptor (TLR)-stimulated dendritic cells (DCs) are able to overcome the inhibitory activity of regulatory T cells (Tregs) and induce the proliferation of effector T cells. TLR-activated DCs secrete a soluble factor and act directly on Tregs to convert them into interferon γ-secreting T(H)1-like cells that express the transcription factor T-bet. Landes Bioscience 2014-01-06 /pmc/articles/PMC4121335/ /pubmed/25101219 http://dx.doi.org/10.4161/onci.27617 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Berk, Erik
Xu, Shuwen
Czerniecki, Brian J
Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
title Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
title_full Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
title_fullStr Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
title_full_unstemmed Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
title_short Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
title_sort dendritic cells matured in the presence of tlr ligands overcome the immunosuppressive functions of regulatory t cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121335/
https://www.ncbi.nlm.nih.gov/pubmed/25101219
http://dx.doi.org/10.4161/onci.27617
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AT czernieckibrianj dendriticcellsmaturedinthepresenceoftlrligandsovercometheimmunosuppressivefunctionsofregulatorytcells

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