MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress

Oxidative stress induces genome-wide remodeling of the chromatin structure. In this study, we identify Methyl-CpG Binding Protein 4 (MBD4), a multifunctional enzyme involved in DNA demethylation, base excision repair, and gene expression regulation, as an essential factor in response to oxidative st...

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Detalles Bibliográficos
Autores principales: Laget, Sophie, Miotto, Benoit, Chin, Hang Gyeong, Estève, Pierre-Olivier, Roberts, Richard J, Pradhan, Sriharsa, Defossez, Pierre-Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121365/
https://www.ncbi.nlm.nih.gov/pubmed/24434851
http://dx.doi.org/10.4161/epi.27695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121365/
https://www.ncbi.nlm.nih.gov/pubmed/24434851
http://dx.doi.org/10.4161/epi.27695

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