Aurora kinase A is a possible target of OSU-03012 to destabilize MYC family proteins

OSU-03012, a 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitor, destabilizes MYCN and MYC proteins in neuroblastoma cells. However, AKT phosphorylation is barely detectable in neuroblastoma cells under normal culture conditions whether treated with OSU-03012 or not. This observation suggests th...

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Detalles Bibliográficos
Autores principales: SILVA, ANDRES, WANG, JENNIE, LOMAHAN, SARAH, TRAN, TUAN-ANH, GRENLIN, LAURA, SUGANAMI, AKIKO, TAMURA, YUTAKA, IKEGAKI, NAOHIKO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121397/
https://www.ncbi.nlm.nih.gov/pubmed/25017515
http://dx.doi.org/10.3892/or.2014.3325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121397/
https://www.ncbi.nlm.nih.gov/pubmed/25017515
http://dx.doi.org/10.3892/or.2014.3325

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