BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

Stable integration in the host genome renders murine leukemia virus (MLV)-derived vectors attractive tools for gene therapy. Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application. MLV and MLV-based vectors integr...

Descripción completa

Detalles Bibliográficos
Autores principales: El Ashkar, Sara, De Rijck, Jan, Demeulemeester, Jonas, Vets, Sofie, Madlala, Paradise, Cermakova, Katerina, Debyser, Zeger, Gijsbers, Rik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121521/
https://www.ncbi.nlm.nih.gov/pubmed/25072693
http://dx.doi.org/10.1038/mtna.2014.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121521/
https://www.ncbi.nlm.nih.gov/pubmed/25072693
http://dx.doi.org/10.1038/mtna.2014.33

Ejemplares similares