Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

The antianginal drug ranolazine, which combines inhibitory actions on rapid and sustained sodium currents with inhibition of the hERG/I(Kr) potassium channel, shows promise as an antiarrhythmic agent. This study investigated the structural basis of hERG block by ranolazine, with lidocaine used as a...

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Detalles Bibliográficos
Autores principales: Du, Chunyun, Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121676/
https://www.ncbi.nlm.nih.gov/pubmed/24877995
http://dx.doi.org/10.1016/j.yjmcc.2014.05.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121676/
https://www.ncbi.nlm.nih.gov/pubmed/24877995
http://dx.doi.org/10.1016/j.yjmcc.2014.05.013

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