Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in sev...

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Detalles Bibliográficos
Autores principales: Xu, Jian, Chatterjee, Manavi, Baguley, Tyler D., Brouillette, Jonathan, Kurup, Pradeep, Ghosh, Debolina, Kanyo, Jean, Zhang, Yang, Seyb, Kathleen, Ononenyi, Chimezie, Foscue, Ethan, Anderson, George M., Gresack, Jodi, Cuny, Gregory D., Glicksman, Marcie A., Greengard, Paul, Lam, TuKiet T., Tautz, Lutz, Nairn, Angus C., Ellman, Jonathan A., Lombroso, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122355/
https://www.ncbi.nlm.nih.gov/pubmed/25093460
http://dx.doi.org/10.1371/journal.pbio.1001923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122355/
https://www.ncbi.nlm.nih.gov/pubmed/25093460
http://dx.doi.org/10.1371/journal.pbio.1001923

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