Cargando…

A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation

Different levels or types of DNA damage activate distinct signaling pathways that elicit various cellular responses, including cell-cycle arrest, DNA repair, senescence, and apoptosis. Whereas a range of DNA-damage responses have been characterized, mechanisms underlying subsequent cell-fate decisio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Lili, Kawai, Hidehiko, Sasatani, Megumi, Iizuka, Daisuke, Masuda, Yuji, Inaba, Toshiya, Suzuki, Keiji, Ootsuyama, Akira, Umata, Toshiyuki, Kamiya, Kenji, Suzuki, Fumio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122452/ https://www.ncbi.nlm.nih.gov/pubmed/25093836 http://dx.doi.org/10.1371/journal.pone.0104279

Ejemplares similares

Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts
por: Shimura, Tsutomu, et al.
Publicado: (2015)

RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure
por: Sasatani, Megumi, et al.
Publicado: (2015)

Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex
por: Masuda, Yuji, et al.
Publicado: (2012)

Metabolomic screening using ESI-FT MS identifies potential radiation-responsive molecules in mouse urine
por: Iizuka, Daisuke, et al.
Publicado: (2017)

Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene
por: Kohzaki, Masaoki, et al.
Publicado: (2021)

Long Bones Exhibit Adaptive Responses to Chronic Low‐Dose‐Rate Ionizing Radiation despite its Lifespan‐Shortening and Carcinogenic Effects on C57BL/6 Mice
por: Kohzaki, Masaoki, et al.
Publicado: (2022)

En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2–E3 pairs
por: Masuda, Yuji, et al.
Publicado: (2012)

Newly discovered genomic mutation patterns in radiation-induced small intestinal tumors of Apc(Min/+) mice
por: Iizuka, Daisuke, et al.
Publicado: (2023)

Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule
por: Iizuka, Daisuke, et al.
Publicado: (2016)

The in vivo role of Rev1 in mutagenesis and carcinogenesis
por: Sasatani, Megumi, et al.
Publicado: (2020)

Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation
por: Meng, Qingmei, et al.
Publicado: (2021)

Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level
por: Sasatani, Megumi, et al.
Publicado: (2017)

Analysis of a lectin microarray identifies altered sialylation of mouse serum glycoproteins induced by whole-body radiation exposure
por: Iizuka, Daisuke, et al.
Publicado: (2019)

Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation
por: Kohzaki, Masaoki, et al.
Publicado: (2023)

Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc(Min/+) mice: possible mechanisms of radiation tumorigenesis
por: Sasatani, Megumi, et al.
Publicado: (2022)

Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade
por: Ding, S L, et al.
Publicado: (2004)

Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy
por: Pan, Yi-Hui, et al.
Publicado: (2021)

Melatonin and MitoEbselen-2 Are Radioprotective Agents to Mitochondria
por: Shimura, Tsutomu, et al.
Publicado: (2022)

Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract
por: Suzuki, Keiji, et al.
Publicado: (2023)

Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver
por: Suzuki, Keiji, et al.
Publicado: (2023)

Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases
por: Suzuki, Keiji, et al.
Publicado: (2010)

Clinical significance of TP53 variants as possible secondary findings in tumor-only next-generation sequencing
por: Yamamoto, Yoshihiro, et al.
Publicado: (2019)

An ATM–Chk2–INCENP pathway activates the abscission checkpoint
por: Petsalaki, Eleni, et al.
Publicado: (2020)

ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation
por: Battu, Aruna, et al.
Publicado: (2011)

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G(2)-checkpoint in S-phase irradiated cells
por: Mladenov, Emil, et al.
Publicado: (2019)

Effect of an Inhibitor of Tumor Promotion, α‐Difluoromethylornithine, on Tumor Induction by Repeated Beta Irradiation in Mice
por: Ootsuyama, Akira, et al.
Publicado: (1993)

Investigation of ATM, TP53 and MDM2 polymorphisms and their association with outcome of radiotherapy for prostate cancer
por: Cintra, Hellen S, et al.
Publicado: (2013)

p53-dependent delayed effects of radiation vary according to time of irradiation of p53 (+ / −) mice
por: Okazaki, Ryuji, et al.
Publicado: (2014)

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
por: Guerra, Lina, et al.
Publicado: (2010)

Shift in G(1)-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation
por: Li, Fanghua, et al.
Publicado: (2021)

Radiation affects glutathione redox reaction by reduced glutathione peroxidase activity in human fibroblasts
por: Shimura, Tsutomu, et al.
Publicado: (2021)

Clonal Origin of Skin and Bone Tumors Produced by Repeated Beta‐irradiation in Mosaic Cell Mice
por: Ootsuyama, Akira, et al.
Publicado: (1992)

Low-Dose-Rate Irradiation Suppresses the Expression of Cell Cycle-Related Genes, Resulting in Modification of Sensitivity to Anti-Cancer Drugs
por: Shimabukuro, Kiichi, et al.
Publicado: (2022)

Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
por: Lazzari, Grazia, et al.
Publicado: (2021)

Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1
por: Yamauchi, Motohiro, et al.
Publicado: (2017)

Association of ATM, CDH1 and TP53 genes polymorphisms with familial breast cancer in patients of Khyber Pakhtunkhwa, Pakistan
por: Rahim, Abdur, et al.
Publicado: (2022)

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
por: Jungmichel, Stephanie, et al.
Publicado: (2012)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks
por: Suzuki, Keiji, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ag6m60m84pd1aqq6kn288hrd5s