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Rer1p regulates the ER retention of immature rhodopsin and modulates its intracellular trafficking

Rhodopsin is a pigment in photoreceptor cells. Some rhodopsin mutations cause the protein to accumulate in the endoplasmic reticulum (ER), leading to photoreceptor degeneration. Although several mutations have been reported, how mutant rhodopsin is retained in the ER remains unclear. In this study,...

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Detalles Bibliográficos
Autores principales: Yamasaki, Akinori, Hara, Taichi, Maejima, Ikuko, Sato, Miyuki, Sato, Katsuya, Sato, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122963/
https://www.ncbi.nlm.nih.gov/pubmed/25096327
http://dx.doi.org/10.1038/srep05973