Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-α

Oxygen deprivation (hypoxia) is a common feature of solid tumors in advanced stages. The primary cellular transcriptional responses to hypoxia are mainly mediated by the transcription factor hypoxia-inducible factor (HIF). HIF consists of an oxygen-labile α-subunit (HIF-1α, -2α) and a stable β-subun...

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Detalles Bibliográficos
Autores principales: Sun, W, Jelkmann, W, Depping, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123088/
https://www.ncbi.nlm.nih.gov/pubmed/25010988
http://dx.doi.org/10.1038/cddis.2014.295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123088/
https://www.ncbi.nlm.nih.gov/pubmed/25010988
http://dx.doi.org/10.1038/cddis.2014.295

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