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DrugTargetSeqR: a genomics- and CRISPR/Cas9-based method to analyze drug targets
To identify the physiological targets of drugs and bioactive small molecules we have developed an approach, named DrugTargetSeqR, which combines high-throughput sequencing, computational mutation discovery and CRISPR/Cas9-based genome editing. We apply this approach to ispinesib and YM155, drugs tha...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123312/ https://www.ncbi.nlm.nih.gov/pubmed/24929528 http://dx.doi.org/10.1038/nchembio.1551 |