Expression, production, and renaturation of a functional single-chain variable antibody fragment (scFv) against human ICAM-1

Intercellular adhesion molecule-1 (ICAM-1) is an important factor in the progression of inflammatory responses in vivo. To develop a new anti-inflammatory drug to block the biological activity of ICAM-1, we produced a monoclonal antibody (Ka=4.19×10(−8) M) against human ICAM-1. The anti-ICAM-1 singl...

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Detalles Bibliográficos
Autores principales: Sun, H., Wu, G.M., Chen, Y.Y., Tian, Y., Yue, Y.H., Zhang, G.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2014
Materias:
Biomedical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123832/
https://www.ncbi.nlm.nih.gov/pubmed/24919171
http://dx.doi.org/10.1590/1414-431X20143276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123832/
https://www.ncbi.nlm.nih.gov/pubmed/24919171
http://dx.doi.org/10.1590/1414-431X20143276

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