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Expression, production, and renaturation of a functional single-chain variable antibody fragment (scFv) against human ICAM-1

Intercellular adhesion molecule-1 (ICAM-1) is an important factor in the progression of inflammatory responses in vivo. To develop a new anti-inflammatory drug to block the biological activity of ICAM-1, we produced a monoclonal antibody (Ka=4.19×10(−8) M) against human ICAM-1. The anti-ICAM-1 singl...

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Detalles Bibliográficos
Autores principales:	Sun, H., Wu, G.M., Chen, Y.Y., Tian, Y., Yue, Y.H., Zhang, G.L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Divulgação Científica 2014
Materias:	Biomedical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123832/ https://www.ncbi.nlm.nih.gov/pubmed/24919171 http://dx.doi.org/10.1590/1414-431X20143276

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