Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-γ-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracil׳s cytotoxicity

Dihomo-γ-linolenic acid (DGLA) and its downstream fatty acid arachidonic acid (AA) are both nutritionally important ω–6 polyunsaturated fatty acids (ω–6s). Evidence shows that, via COX-mediated peroxidation, DGLA and its metabolites (1-series prostaglandins) are associated with anti-tumor activity,...

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Detalles Bibliográficos
Autores principales: Xu, Yi, Qi, Jin, Yang, Xiaoyu, Wu, Erxi, Qian, Steven Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124262/
https://www.ncbi.nlm.nih.gov/pubmed/25114837
http://dx.doi.org/10.1016/j.redox.2014.01.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124262/
https://www.ncbi.nlm.nih.gov/pubmed/25114837
http://dx.doi.org/10.1016/j.redox.2014.01.022

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