A simple structure-based model for the prediction of HIV-1 co-receptor tropism

BACKGROUND: Human Immunodeficiency Virus 1 enters host cells through interaction of its V3 loop (which is part of the gp120 protein) with the host cell receptor CD4 and one of two co-receptors, namely CCR5 or CXCR4. Entry inhibitors binding the CCR5 co-receptor can prevent viral entry. As these drug...

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Detalles Bibliográficos
Autores principales: Heider, Dominik, Dybowski, Jan Nikolaj, Wilms, Christoph, Hoffmann, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124776/
https://www.ncbi.nlm.nih.gov/pubmed/25120583
http://dx.doi.org/10.1186/1756-0381-7-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124776/
https://www.ncbi.nlm.nih.gov/pubmed/25120583
http://dx.doi.org/10.1186/1756-0381-7-14

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