Reduction of meckelin leads to general loss of cilia, ciliary microtubule misalignment and distorted cell surface organization

BACKGROUND: Meckelin (MKS3), a conserved protein linked to Meckel Syndrome, assists in the migration of centrioles to the cell surface for ciliogenesis. We explored for additional functions of MKS3p using RNA interference (RNAi) and expression of FLAG epitope tagged protein in the ciliated protozoan...

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Detalles Bibliográficos
Autores principales: Picariello, Tyler, Valentine, Megan Smith, Yano, Junji, Van Houten, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124839/
https://www.ncbi.nlm.nih.gov/pubmed/24484742
http://dx.doi.org/10.1186/2046-2530-3-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124839/
https://www.ncbi.nlm.nih.gov/pubmed/24484742
http://dx.doi.org/10.1186/2046-2530-3-2

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