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Reduction of meckelin leads to general loss of cilia, ciliary microtubule misalignment and distorted cell surface organization
BACKGROUND: Meckelin (MKS3), a conserved protein linked to Meckel Syndrome, assists in the migration of centrioles to the cell surface for ciliogenesis. We explored for additional functions of MKS3p using RNA interference (RNAi) and expression of FLAG epitope tagged protein in the ciliated protozoan...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124839/ https://www.ncbi.nlm.nih.gov/pubmed/24484742 http://dx.doi.org/10.1186/2046-2530-3-2 |