Creation of a gated antibody as a conditionally functional synthetic protein

The ability to conditionally direct antibodies is a potentially powerful application for Synthetic Biology in Medicine. Here we show that control of antibody binding through site-specific, chemical phosphorylation of a recognition domain creates a ‘gated’ antibody (Ab). This displays a crude Boolean...

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Detalles Bibliográficos
Autores principales: Gunnoo, Smita B., Finney, Helene M., Baker, Terry S., Lawson, Alastair D., Anthony, Daniel C., Davis, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124856/
https://www.ncbi.nlm.nih.gov/pubmed/25073737
http://dx.doi.org/10.1038/ncomms5388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124856/
https://www.ncbi.nlm.nih.gov/pubmed/25073737
http://dx.doi.org/10.1038/ncomms5388

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