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Modest Ca(V)1.3(42)-selective inhibition by compound 8 is β-subunit dependent

Two voltage-gated calcium channel subtypes—Ca(V)1.2 and Ca(V)1.3—underlie the major L-type Ca(2+) currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties, and at high doses classic calcium channel bloc...

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Detalles Bibliográficos
Autores principales: Huang, Hua, Ng, Cheng Yang, Yu, Dejie, Zhai, Jing, Lam, Yulin, Soong, Tuck Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124865/
https://www.ncbi.nlm.nih.gov/pubmed/25057870
http://dx.doi.org/10.1038/ncomms5481