Modest Ca(V)1.3(42)-selective inhibition by compound 8 is β-subunit dependent

Two voltage-gated calcium channel subtypes—Ca(V)1.2 and Ca(V)1.3—underlie the major L-type Ca(2+) currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties, and at high doses classic calcium channel bloc...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Hua, Ng, Cheng Yang, Yu, Dejie, Zhai, Jing, Lam, Yulin, Soong, Tuck Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124865/
https://www.ncbi.nlm.nih.gov/pubmed/25057870
http://dx.doi.org/10.1038/ncomms5481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124865/
https://www.ncbi.nlm.nih.gov/pubmed/25057870
http://dx.doi.org/10.1038/ncomms5481

Ejemplares similares