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Modest Ca(V)1.3(42)-selective inhibition by compound 8 is β-subunit dependent
Two voltage-gated calcium channel subtypes—Ca(V)1.2 and Ca(V)1.3—underlie the major L-type Ca(2+) currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties, and at high doses classic calcium channel bloc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124865/ https://www.ncbi.nlm.nih.gov/pubmed/25057870 http://dx.doi.org/10.1038/ncomms5481 |