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A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation
In a previous work by Alvarez-Martinez et al. (2011), the authors pointed out some fallacies in the mainstream interpretation of the prion amyloid formation. It appeared necessary to propose an original hypothesis able to reconcile the in vitro data with the predictions of a mathematical model descr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125056/ https://www.ncbi.nlm.nih.gov/pubmed/25101755 http://dx.doi.org/10.1371/journal.pcbi.1003735 |
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author | Hingant, Erwan Fontes, Pascaline Alvarez-Martinez, Maria Teresa Arnaud, Jacques-Damien Liautard, Jean-Pierre Pujo-Menjouet, Laurent |
author_facet | Hingant, Erwan Fontes, Pascaline Alvarez-Martinez, Maria Teresa Arnaud, Jacques-Damien Liautard, Jean-Pierre Pujo-Menjouet, Laurent |
author_sort | Hingant, Erwan |
collection | PubMed |
description | In a previous work by Alvarez-Martinez et al. (2011), the authors pointed out some fallacies in the mainstream interpretation of the prion amyloid formation. It appeared necessary to propose an original hypothesis able to reconcile the in vitro data with the predictions of a mathematical model describing the problem. Here, a model is developed accordingly with the hypothesis that an intermediate on-pathway leads to the conformation of the prion protein into an amyloid competent isoform thanks to a structure, called micelles, formed from hydrodynamic interaction. The authors also compare data to the prediction of their model and propose a new hypothesis for the formation of infectious prion amyloids. |
format | Online Article Text |
id | pubmed-4125056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41250562014-08-12 A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation Hingant, Erwan Fontes, Pascaline Alvarez-Martinez, Maria Teresa Arnaud, Jacques-Damien Liautard, Jean-Pierre Pujo-Menjouet, Laurent PLoS Comput Biol Research Article In a previous work by Alvarez-Martinez et al. (2011), the authors pointed out some fallacies in the mainstream interpretation of the prion amyloid formation. It appeared necessary to propose an original hypothesis able to reconcile the in vitro data with the predictions of a mathematical model describing the problem. Here, a model is developed accordingly with the hypothesis that an intermediate on-pathway leads to the conformation of the prion protein into an amyloid competent isoform thanks to a structure, called micelles, formed from hydrodynamic interaction. The authors also compare data to the prediction of their model and propose a new hypothesis for the formation of infectious prion amyloids. Public Library of Science 2014-08-07 /pmc/articles/PMC4125056/ /pubmed/25101755 http://dx.doi.org/10.1371/journal.pcbi.1003735 Text en © 2014 Hingant et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hingant, Erwan Fontes, Pascaline Alvarez-Martinez, Maria Teresa Arnaud, Jacques-Damien Liautard, Jean-Pierre Pujo-Menjouet, Laurent A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation |
title | A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation |
title_full | A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation |
title_fullStr | A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation |
title_full_unstemmed | A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation |
title_short | A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation |
title_sort | micellar on-pathway intermediate step explains the kinetics of prion amyloid formation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125056/ https://www.ncbi.nlm.nih.gov/pubmed/25101755 http://dx.doi.org/10.1371/journal.pcbi.1003735 |
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