The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing

Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design vaccine immunogens that lead to impair...

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Detalles Bibliográficos
Autores principales: Mann, Jaclyn K., Barton, John P., Ferguson, Andrew L., Omarjee, Saleha, Walker, Bruce D., Chakraborty, Arup, Ndung'u, Thumbi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125067/
https://www.ncbi.nlm.nih.gov/pubmed/25102049
http://dx.doi.org/10.1371/journal.pcbi.1003776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125067/
https://www.ncbi.nlm.nih.gov/pubmed/25102049
http://dx.doi.org/10.1371/journal.pcbi.1003776

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