A Novel Dual Allosteric Activation Mechanism of Escherichia coli ADP-Glucose Pyrophosphorylase: The Role of Pyruvate

Fructose-1,6-bisphosphate activates ADP-glucose pyrophosphorylase and the synthesis of glycogen in Escherichia coli. Here, we show that although pyruvate is a weak activator by itself, it synergically enhances the fructose-1,6-bisphosphate activation. They increase the enzyme affinity for each other...

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Detalles Bibliográficos
Autores principales: Asención Diez, Matías D., Aleanzi, Mabel C., Iglesias, Alberto A., Ballicora, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125136/
https://www.ncbi.nlm.nih.gov/pubmed/25102309
http://dx.doi.org/10.1371/journal.pone.0103888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125136/
https://www.ncbi.nlm.nih.gov/pubmed/25102309
http://dx.doi.org/10.1371/journal.pone.0103888

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