Dual-Color Fluorescence Imaging to Monitor CYP3A4 and CYP3A7 Expression in Human Hepatic Carcinoma HepG2 and HepaRG Cells

Human adult hepatocytes expressing CYP3A4, a major cytochrome P450 enzyme, are required for cell-based assays to evaluate the potential risk of drug-drug interactions caused by transcriptional induction of P450 enzymes in early-phase drug discovery and development. However, CYP3A7 is preferentially...

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Detalles Bibliográficos
Autores principales: Tsuji, Saori, Kawamura, Fumihiko, Kubiura, Musashi, Hayashi, Ayaka, Ohbayashi, Tetsuya, Kazuki, Yasuhiro, Chesné, Christophe, Oshimura, Mitsuo, Tada, Masako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125183/
https://www.ncbi.nlm.nih.gov/pubmed/25101946
http://dx.doi.org/10.1371/journal.pone.0104123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125183/
https://www.ncbi.nlm.nih.gov/pubmed/25101946
http://dx.doi.org/10.1371/journal.pone.0104123

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