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The Murine Gammaherpesvirus Immediate-Early Rta Synergizes with IRF4, Targeting Expression of the Viral M1 Superantigen to Plasma Cells

MHV68 is a murine gammaherpesvirus that infects laboratory mice and thus provides a tractable small animal model for characterizing critical aspects of gammaherpesvirus pathogenesis. Having evolved with their natural host, herpesviruses encode numerous gene products that are involved in modulating h...

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Detalles Bibliográficos
Autores principales: O'Flaherty, Brigid M., Soni, Tanushree, Wakeman, Brian S., Speck, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125235/
https://www.ncbi.nlm.nih.gov/pubmed/25101696
http://dx.doi.org/10.1371/journal.ppat.1004302