Identification of genes in trinucleotide repeat RNA toxicity pathways in C. elegans

Myotonic dystrophy disorders are caused by expanded CUG repeats in non-coding regions. To reveal mechanisms of CUG repeat pathogenesis we used C. elegans expressing CUG repeats to identify gene inactivations that modulate CUG repeat toxicity. We identified 15 conserved genes that function as suppres...

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Detalles Bibliográficos
Autores principales: Garcia, Susana M. D. A., Tabach, Yuval, Lourenço, Guinevere F., Armakola, Maria, Ruvkun, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125460/
https://www.ncbi.nlm.nih.gov/pubmed/25038802
http://dx.doi.org/10.1038/nsmb.2858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125460/
https://www.ncbi.nlm.nih.gov/pubmed/25038802
http://dx.doi.org/10.1038/nsmb.2858

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