The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells

Immune evasion is a hallmark of cancer. We recently identified the adhesion molecule L1CAM as biomarker of pancreatic ductal adenocarcinoma (PDAC) associated with poor prognosis. During inflammation-associated carcinogenesis, L1CAM drives the enrichment of highly immunosuppressive CD4(+)CD25(-)CD69(...

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Autores principales: Grage-Griebenow, Evelin, Schäfer, Heiner, Sebens, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126073/
https://www.ncbi.nlm.nih.gov/pubmed/25114835
http://dx.doi.org/10.4161/onci.29382
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author Grage-Griebenow, Evelin
Schäfer, Heiner
Sebens, Susanne
author_facet Grage-Griebenow, Evelin
Schäfer, Heiner
Sebens, Susanne
author_sort Grage-Griebenow, Evelin
collection PubMed
description Immune evasion is a hallmark of cancer. We recently identified the adhesion molecule L1CAM as biomarker of pancreatic ductal adenocarcinoma (PDAC) associated with poor prognosis. During inflammation-associated carcinogenesis, L1CAM drives the enrichment of highly immunosuppressive CD4(+)CD25(-)CD69(+) T cells. Thus, L1CAM may serve as a target in immunomodulatory therapy for PDAC.
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spelling pubmed-41260732014-08-11 The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells Grage-Griebenow, Evelin Schäfer, Heiner Sebens, Susanne Oncoimmunology Author's View Immune evasion is a hallmark of cancer. We recently identified the adhesion molecule L1CAM as biomarker of pancreatic ductal adenocarcinoma (PDAC) associated with poor prognosis. During inflammation-associated carcinogenesis, L1CAM drives the enrichment of highly immunosuppressive CD4(+)CD25(-)CD69(+) T cells. Thus, L1CAM may serve as a target in immunomodulatory therapy for PDAC. Landes Bioscience 2014-06-25 /pmc/articles/PMC4126073/ /pubmed/25114835 http://dx.doi.org/10.4161/onci.29382 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Grage-Griebenow, Evelin
Schäfer, Heiner
Sebens, Susanne
The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
title The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
title_full The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
title_fullStr The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
title_full_unstemmed The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
title_short The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
title_sort fatal alliance of cancer and t cells: how pancreatic tumor cells gather immunosuppressive t cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126073/
https://www.ncbi.nlm.nih.gov/pubmed/25114835
http://dx.doi.org/10.4161/onci.29382
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