Calcium Current Inactivation Rather than Pool Depletion Explains Reduced Exocytotic Rate with Prolonged Stimulation in Insulin-Secreting INS-1 832/13 Cells

Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca(2+)-dependent insulin exocytosis with respect to pool depletion and Ca(2+)-current inactivation. We studied exocytosis, measured as increase in membrane capac...

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Detalles Bibliográficos
Autores principales: Pedersen, Morten Gram, Salunkhe, Vishal Ashok, Svedin, Emma, Edlund, Anna, Eliasson, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126658/
https://www.ncbi.nlm.nih.gov/pubmed/25105407
http://dx.doi.org/10.1371/journal.pone.0103874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126658/
https://www.ncbi.nlm.nih.gov/pubmed/25105407
http://dx.doi.org/10.1371/journal.pone.0103874

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