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Calcium Current Inactivation Rather than Pool Depletion Explains Reduced Exocytotic Rate with Prolonged Stimulation in Insulin-Secreting INS-1 832/13 Cells
Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca(2+)-dependent insulin exocytosis with respect to pool depletion and Ca(2+)-current inactivation. We studied exocytosis, measured as increase in membrane capac...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126658/ https://www.ncbi.nlm.nih.gov/pubmed/25105407 http://dx.doi.org/10.1371/journal.pone.0103874 |