STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression

The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs).(1,2) We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of R...

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Autores principales: Le Bert, Nina, Lam, Adeline R, Ho, Samantha SW, Shen, Yu J, Liu, Mo M, Gasser, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126837/
https://www.ncbi.nlm.nih.gov/pubmed/25114832
http://dx.doi.org/10.4161/onci.29259
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author Le Bert, Nina
Lam, Adeline R
Ho, Samantha SW
Shen, Yu J
Liu, Mo M
Gasser, Stephan
author_facet Le Bert, Nina
Lam, Adeline R
Ho, Samantha SW
Shen, Yu J
Liu, Mo M
Gasser, Stephan
author_sort Le Bert, Nina
collection PubMed
description The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs).(1,2) We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of RAE-1 ligands for NKG2D.(3)
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spelling pubmed-41268372014-08-11 STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression Le Bert, Nina Lam, Adeline R Ho, Samantha SW Shen, Yu J Liu, Mo M Gasser, Stephan Oncoimmunology Author's View The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs).(1,2) We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of RAE-1 ligands for NKG2D.(3) Landes Bioscience 2014-06-25 /pmc/articles/PMC4126837/ /pubmed/25114832 http://dx.doi.org/10.4161/onci.29259 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Le Bert, Nina
Lam, Adeline R
Ho, Samantha SW
Shen, Yu J
Liu, Mo M
Gasser, Stephan
STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression
title STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression
title_full STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression
title_fullStr STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression
title_full_unstemmed STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression
title_short STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression
title_sort sting-dependent cytosolic dna sensor pathways regulate nkg2d ligand expression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126837/
https://www.ncbi.nlm.nih.gov/pubmed/25114832
http://dx.doi.org/10.4161/onci.29259
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