Cargando…

STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression

The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs).(1,2) We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Le Bert, Nina, Lam, Adeline R, Ho, Samantha SW, Shen, Yu J, Liu, Mo M, Gasser, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126837/ https://www.ncbi.nlm.nih.gov/pubmed/25114832 http://dx.doi.org/10.4161/onci.29259

Ejemplares similares

NKG2D ligands link oncogenic RAS to innate immunity
por: Ho, Samantha S.W., et al.
Publicado: (2013)

Tumor suppressors control ULBP2, an innate surface ligand of the lymphocyte immune receptor NKG2D
por: Heinemann, Anja, et al.
Publicado: (2012)

Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma
por: Soriani, Alessandra, et al.
Publicado: (2013)

Regulation of NKG2D signaling during the epithelial-to-mesenchymal transition
por: López-Soto, Alejandro, et al.
Publicado: (2013)

cGAS-independent STING activation in response to DNA damage
por: Unterholzner, Leonie, et al.
Publicado: (2019)

Cytosolic pH: A conserved regulator of cell growth?
por: Dechant, Reinhard, et al.
Publicado: (2014)

Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
por: Alkan, H. Furkan, et al.
Publicado: (2019)

Metastamir-mediated immune evasion: miR-10b downregulates the stress-induced molecule MICB, hence avoid recognition by NKG2D receptor
por: Tsukerman, Pinchas, et al.
Publicado: (2013)

ATM activation mediates anticancer immunosurveillance by natural killer and T cells
por: Tang, Melissa LF, et al.
Publicado: (2013)

Out of the bitter came forth sweet: Activating CD28-dependent co-stimulation via PD-1 ligands
por: Ankri, Chen, et al.
Publicado: (2014)

The role of FOXP3 in disease progression in colorectal cancer patients
por: Grimmig, Tanja, et al.
Publicado: (2013)

Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
por: Chew, Valerie, et al.
Publicado: (2013)

Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand
por: Préville, Xavier, et al.
Publicado: (2015)

Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
por: Dentelli, Patrizia, et al.
Publicado: (2014)

Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
por: Berk, Erik, et al.
Publicado: (2014)

Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
por: Shirwan, Haval, et al.
Publicado: (2013)

JmjC histone demethylases act as chromatin oxygen sensors
por: Batie, Michael, et al.
Publicado: (2019)

Context-dependent utilization of serine in cancer
por: Mehrmohamadi, Mahya, et al.
Publicado: (2015)

Author Correction: Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer
por: Frittoli, Emanuela, et al.
Publicado: (2023)

PSPC1 potentiates TGF-β-dependent metastatic dissemination
por: Yeh, Hsi-Wen, et al.
Publicado: (2018)

Transcription-dependent DNA double-strand breaks and human disease
por: Cristini, Agnese, et al.
Publicado: (2020)

TFG: a novel regulator of ULK1-dependent autophagy
por: Cecconi, Francesco, et al.
Publicado: (2021)

FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming
por: Gingras, Marie-Claude, et al.
Publicado: (2014)

NORRIN plays a context-dependent role in glioblastoma stem cells
por: El-Sehemy, Ahmed, et al.
Publicado: (2020)

Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
por: Ma, Yuting, et al.
Publicado: (2019)

Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity
por: Garg, Abhishek D, et al.
Publicado: (2013)

BORA-dependent PLK1 regulation: A new weapon for cancer therapy?
por: Cirillo, Luca, et al.
Publicado: (2016)

Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer
por: Xing, Zhen, et al.
Publicado: (2015)

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
por: Seki, Ekihiro
Publicado: (2014)

The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling
por: Gallagher, Ewen, et al.
Publicado: (2015)

Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
por: Giambruno, Roberto, et al.
Publicado: (2020)

RB1-mediated cell-autonomous and host-dependent oncosuppressor mechanisms in radiation-induced osteosarcoma
por: Kansara, Maya, et al.
Publicado: (2014)

Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
por: Leverson, Joel D.
Publicado: (2015)

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy
por: Ma, Yuting, et al.
Publicado: (2013)

Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
por: Houot, Roch, et al.
Publicado: (2012)

Triple threat treatment: Exploiting the dependence receptor properties of metabotropic glutamate receptor 1 against melanoma
por: Gelb, Tara, et al.
Publicado: (2014)

NSD1 in erythroid differentiation and leukemogenesis
por: Tauchmann, Samantha, et al.
Publicado: (2020)

Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms
por: Das, Mrinmoy, et al.
Publicado: (2020)

c-Abl forces YAP to switch sides
por: Keshet, Rom, et al.
Publicado: (2015)

Inducing DNA damage through R-loops to kill cancer cells
por: Lam, Fred C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gj8gdj4ir0jc20ljgrdda8v935