Synthesis, central nervous system activity, and structure–activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones

A series of 24 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones was designed as antinociceptive compounds acting through opioid receptors with additional serotoninergic activity. The compounds, similarly as previously published series, lack the protonable nitrogen atom which...

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Detalles Bibliográficos
Autores principales: Rządkowska, Marzena, Szacoń, Elżbieta, Kaczor, Agnieszka A., Fidecka, Sylwia, Kędzierska, Ewa, Matosiuk, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127001/
https://www.ncbi.nlm.nih.gov/pubmed/25132789
http://dx.doi.org/10.1007/s00044-014-0993-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127001/
https://www.ncbi.nlm.nih.gov/pubmed/25132789
http://dx.doi.org/10.1007/s00044-014-0993-1

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