MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1

Mutations in the neurofibromatosis type 1 (NF1 tumor suppressor gene are common in cancer, and can cause resistance to therapy. Using transcriptome analysis we identified MAF as an NF1 regulated transcription factor, and verified MAF regulation through RAS/MAPK/AP-1 signaling in malignant peripheral...

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Detalles Bibliográficos
Autores principales: Brundage, Meghan E., Tandon, Preeti, Eaves, David W., Williams, Jon P., Miller, Shyra J., Hennigan, Robert H., Jegga, Anil, Cripe, Timothy P., Ratner, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127377/
https://www.ncbi.nlm.nih.gov/pubmed/24509877
http://dx.doi.org/10.1038/onc.2013.506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127377/
https://www.ncbi.nlm.nih.gov/pubmed/24509877
http://dx.doi.org/10.1038/onc.2013.506

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