SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway

Sirtuins are NAD-dependent protein deacetylases that were shown to have protective effects against different age-related diseases. SIRT2 is a strong deacetylase that is highly expressed in brain. It has been associated with neurodegenerative diseases. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridi...

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Detalles Bibliográficos
Autores principales: Liu, Lei, Arun, Anirudh, Ellis, Lakia, Peritore, Carina, Donmez, Gizem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127494/
https://www.ncbi.nlm.nih.gov/pubmed/25157229
http://dx.doi.org/10.3389/fnagi.2014.00184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127494/
https://www.ncbi.nlm.nih.gov/pubmed/25157229
http://dx.doi.org/10.3389/fnagi.2014.00184

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