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Controlling resistant bacteria with a novel class of β-lactamase inhibitor peptides: from rational design to in vivo analyses

Peptide rational design was used here to guide the creation of two novel short β-lactamase inhibitors, here named dBLIP-1 and -2, with length of five amino acid residues. Molecular modeling associated with peptide synthesis improved bactericidal efficacy in addition to amoxicillin, ampicillin and ce...

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Detalles Bibliográficos
Autores principales: Mandal, Santi M., Migliolo, Ludovico, Silva, Osmar N., Fensterseifer, Isabel C. M., Faria-Junior, Celio, Dias, Simoni C., Basak, Amit, Hazra, Tapas K., Franco, Octávio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127500/
https://www.ncbi.nlm.nih.gov/pubmed/25109311
http://dx.doi.org/10.1038/srep06015