A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits

BACKGROUND: 11ß–hydroxysteroid dehydrogenase type1 (11β-HSD1) converts inactive glucocorticoids to active glucocorticoids which, in excess, leads to development of the various risk factors of the metabolic syndrome. Recent studies clearly suggest that both increased expression and activity of 11β-HS...

Descripción completa

Detalles Bibliográficos
Autores principales: Anil, Tharappel M, Dandu, Anilkumar, Harsha, KrishnaReddy, Singh, Jaideep, Shree, Nitya, Kumar, Venkatesh Satish, Lakshmi, Mudigere N, Sunil, Venkategowda, Harish, Chandrashekaran, Balamurali, Gundalmandikal V, Naveen Kumar, Baisani S, Gopala, Aralakuppe S, Pratibha, Shivakumar, Sadasivuni, ManojKumar, Anup, Mammen O, Moolemath, Yoganand, Venkataranganna, Marikunte V, Jagannath, Madanahalli R, Somesh, Baggavalli P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127523/
https://www.ncbi.nlm.nih.gov/pubmed/25098735
http://dx.doi.org/10.1186/2050-6511-15-43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127523/
https://www.ncbi.nlm.nih.gov/pubmed/25098735
http://dx.doi.org/10.1186/2050-6511-15-43

Ejemplares similares