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Cytotoxicity of dietary flavonoids on different human cancer types

Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Mal...

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Autor principal: Sak, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127821/
https://www.ncbi.nlm.nih.gov/pubmed/25125885
http://dx.doi.org/10.4103/0973-7847.134247
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author Sak, Katrin
author_facet Sak, Katrin
author_sort Sak, Katrin
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description Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, therefore, the preferences of the most common dietary flavonoids to various human cancer types are analyzed in this review. While luteolin and kaempferol can be considered as promising candidate agents for treatment of gastric and ovarian cancers, respectively, apigenin, chrysin, and luteolin have good perspectives as potent antitumor agents for cervical cancer; cells from main sites of flavonoid metabolism (colon and liver) reveal rather large fluctuations in anticancer activity probably due to exposure to various metabolites with different activities. Anticancer effect of flavonoids toward blood cancer cells depend on their myeloid, lymphoid, or erythroid origin; cytotoxic effects of flavonoids on breast and prostate cancer cells are highly related to the expression of hormone receptors. Different flavonoids are often preferentially present in certain food items, and knowledge about the malignant tissue-specific anticancer effects of flavonoids could be purposely applied both in chemoprevention as well as in cancer treatment.
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spelling pubmed-41278212014-08-14 Cytotoxicity of dietary flavonoids on different human cancer types Sak, Katrin Pharmacogn Rev Review Article Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, therefore, the preferences of the most common dietary flavonoids to various human cancer types are analyzed in this review. While luteolin and kaempferol can be considered as promising candidate agents for treatment of gastric and ovarian cancers, respectively, apigenin, chrysin, and luteolin have good perspectives as potent antitumor agents for cervical cancer; cells from main sites of flavonoid metabolism (colon and liver) reveal rather large fluctuations in anticancer activity probably due to exposure to various metabolites with different activities. Anticancer effect of flavonoids toward blood cancer cells depend on their myeloid, lymphoid, or erythroid origin; cytotoxic effects of flavonoids on breast and prostate cancer cells are highly related to the expression of hormone receptors. Different flavonoids are often preferentially present in certain food items, and knowledge about the malignant tissue-specific anticancer effects of flavonoids could be purposely applied both in chemoprevention as well as in cancer treatment. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4127821/ /pubmed/25125885 http://dx.doi.org/10.4103/0973-7847.134247 Text en Copyright: © Pharmacognosy Reviews http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sak, Katrin
Cytotoxicity of dietary flavonoids on different human cancer types
title Cytotoxicity of dietary flavonoids on different human cancer types
title_full Cytotoxicity of dietary flavonoids on different human cancer types
title_fullStr Cytotoxicity of dietary flavonoids on different human cancer types
title_full_unstemmed Cytotoxicity of dietary flavonoids on different human cancer types
title_short Cytotoxicity of dietary flavonoids on different human cancer types
title_sort cytotoxicity of dietary flavonoids on different human cancer types
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127821/
https://www.ncbi.nlm.nih.gov/pubmed/25125885
http://dx.doi.org/10.4103/0973-7847.134247
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