PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia

BACKGROUND: Poly(ADP-ribose) polymerase 1 (PARP1) is a chromatin-associated enzyme that participates in processes such as transcription and DNA repair through the regulation of chromatin structure. Accumulating evidence suggests an important role for PARP1 enzymatic activity in promoting CNS inflamm...

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Detalles Bibliográficos
Autores principales: Martínez-Zamudio, Ricardo Iván, Ha, Hyo Chol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128037/
https://www.ncbi.nlm.nih.gov/pubmed/25161822
http://dx.doi.org/10.1002/brb3.239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128037/
https://www.ncbi.nlm.nih.gov/pubmed/25161822
http://dx.doi.org/10.1002/brb3.239

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