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PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia
BACKGROUND: Poly(ADP-ribose) polymerase 1 (PARP1) is a chromatin-associated enzyme that participates in processes such as transcription and DNA repair through the regulation of chromatin structure. Accumulating evidence suggests an important role for PARP1 enzymatic activity in promoting CNS inflamm...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Blackwell Publishing Ltd
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128037/ https://www.ncbi.nlm.nih.gov/pubmed/25161822 http://dx.doi.org/10.1002/brb3.239 |