Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

BACKGROUND AND PURPOSE: The highly conserved tryptophan (W6.48) in transmembrane domain 6 of GPCRs has been shown to play a central role in forming an active conformation in response to agonist binding. We set out to characterize the effect of this mutation on the efficacy of two agonists at multipl...

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Detalles Bibliográficos
Autores principales: Stoddart, Leigh A, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128046/
https://www.ncbi.nlm.nih.gov/pubmed/24750014
http://dx.doi.org/10.1111/bph.12739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128046/
https://www.ncbi.nlm.nih.gov/pubmed/24750014
http://dx.doi.org/10.1111/bph.12739

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