Inactivation of thyA in Staphylococcus aureus Attenuates Virulence and Has a Strong Impact on Metabolism and Virulence Gene Expression

Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs) are frequently isolated from patients with chronic S. aureus infections after long-term treatment with trimethoprim-sulfamethoxazole (TMP-SMX). While it has been shown that TD-SCVs were associated with mutations in thymidylate...

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Detalles Bibliográficos
Autores principales: Kriegeskorte, Andre, Block, Desiree, Drescher, Mike, Windmüller, Nadine, Mellmann, Alexander, Baum, Cathrin, Neumann, Claudia, Lorè, Nicola Ivan, Bragonzi, Alessandra, Liebau, Eva, Hertel, Patrick, Seggewiss, Jochen, Becker, Karsten, Proctor, Richard A., Peters, Georg, Kahl, Barbara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128360/
https://www.ncbi.nlm.nih.gov/pubmed/25073642
http://dx.doi.org/10.1128/mBio.01447-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128360/
https://www.ncbi.nlm.nih.gov/pubmed/25073642
http://dx.doi.org/10.1128/mBio.01447-14

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